@Soyweiser You’re assuming the first Starship to Mars has a cargo of canned primates. Rest assured, it can’t and it won’t. (Also, I doubt Starship will be ready for Mars—extended duration in space, remember—in time for the 2026 launch window. Although a robot probe as a payload launched atop Starship is entirely possible in that time frame: you don’t need reusability, just a bloody big payload bay and the ability to reach orbit once, which Starship achieved as of OFT-3.)
@mountainriver Also of note: the Helios Airways Flight 522 disaster. (Loaded 737 crashed, everybody killed … because of a locked cockpit door: plane depressurized and pilots’ oxygen failed, cabin crew—inc. a pilot—were unable to gain cockpit access in time to save the plane before it ran out of fuel and crashed.) https://en.wikipedia.org/wiki/Helios_Airways_Flight_522